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Combination with Obesity Increases Risk of Birth Defects.(diabetes )
2001 JAN 11 - (NewsRx.com) -- Women who are both obese and diabetic have a much greater risk than other women of giving birth to children with congenital birth defects, according to researchers in the United States.
L.L. Moore and colleagues at Boston University conducted a study to "evaluate the effects of maternal obesity and diabetes mellitus on the risk of nonchromosomal congenital defects," the results of which were published in the journal Epidemiology.
The researchers reviewed medical information from more than 20,000 pregnant women who participated in a study on the effects of a variety of prenatal exposures ("A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus," Epidemiol, November 2000;11(6):689-694).
Women who were obese but not diabetic did not have a greater proportion of children with major congenital defects, they found. However, some defects were overrepresented in the children of obese women, including cleft lips and/or palates, club feet, and defects in the septum of the heart. In addition, obese women also tended, to a lesser extent, to have more children with abdominal wall defects and/or hydrocephaly.
Similarly, non-obese women with diabetes had no greater risk of giving birth to children with major birth defects, but those who did tended to have children with musculoskeletal defects, study data showed.
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Source: HighBeam Research, Combination with Obesity Increases Risk of Birth Defects.(diabetes )