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Fetal Cells in Liver after Pregnancy May be Cause of Cholestatic Liver Disease.
2001 JAN 11 - (NewsRx.com) -- Scientists report in the Journal of Hepatology that a serious liver ailment known to predominantly affect middle-aged women may be caused by fetal cells in the women's livers that remain after pregnancy.
Microchimerism, or the presence of fetal cells that remain in maternal tissues or blood after pregnancy, also occurs when donor cells are grafted into a host recipient. Scientists report that primary biliary cirrhosis has manifestations similar to those seen in hepatic graft-versus-host disease.
"Primary biliary cirrhosis is a chronic cholestatic liver disease characterized by progressive inflammatory destruction of bile ducts, with eventual hepatic fibrosis and cirrhosis," described P.A. Fanning et al. of Prince Alexandra Hospital in Australia.
To test the microchimerism theory, researchers studied the blood and liver biopsies of 18 women with primary biliary cirrhosis, 20 women with chronic hepatitis C or alcoholic liver disease, and 18 healthy controls.
"Male cells were detected in liver biopsy specimens of eight of 19 patients (42%) with primary biliary cirrhosis," Fanning et al. noted.
In contrast, no cells containing Y chromosomes were found in any of the liver biopsy samples from women with the other ...
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Source: HighBeam Research, Fetal Cells in Liver after Pregnancy May be Cause of Cholestatic...