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Growth Factor Could Predict Disease Course.(vascular endothelial growth factor, cervical cancer)
2001 JAN 11 - (NewsRx.com) -- by Sonia Bell-Nichols, staff medical writer -- Vascular endothelial growth factor (VEGF) has been proposed as a marker for a variety of types of cancers. New research indicates that VEGF could some day be used to predict the course of cervical cancer and lymph node invasion in women with early stage cancers.
Increased VEGF expression has long been associated with the growth of new blood vessels needed for cancer tumors to grow and survive.
This newest research was conducted in Taiwan at the National Taiwan University hospital, where cancer tumors and lymph nodes from 135 women with stage IB-IIA cervical cancer were evaluated for histological appearance as well as the presence of cytosol VEGF.
"Twenty-two women (16.3%) who had disease recurrence had higher levels of cytosol VEGF (1,020 versus 112 pg/mg protein, P[less than].001) than those without recurrence," stated W.F. Cheng and research colleagues.
They reported the sensitivity, specificity, positive predictive value, and negative predictive value of using VEGF as a prognostic indicator was 75%, 70%, 41%, and 92%, respectively, using a cutoff value of 400 pg/ml ("Vascular endothelial growth factor and prognosis of cervical carcinoma," Obstetrics and Gynecology, 2000;96(5) Part 1):721-726).
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Source: HighBeam Research, Growth Factor Could Predict Disease Course.(vascular endothelial...