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Cervical Carcinogenesis Curbed by HPV Oncogene Repression.(human papillomavirus )
2001 JAN 11 -- (NewsRx.com) -- Repression of human papillomavirus (HPV) E6 and E7 proteins can reverse cervical carcinogenesis.
How? These proteins neutralize cells' natural tumor suppressor function, report researchers from Yale University's School of Medicine in Connecticut.
E.C. Goodwin and associates investigated these proteins' roles in cervical carcinogenesis, and their findings were dramatic.
"This dynamic response strongly suggests that the p53 and Rb tumor suppressor pathways are intact in HeLa cells and that repression of HPV E6 and E7 mobilizes these pathways in an orderly fashion to deliver growth inhibitory signals to the cells," they reported in a study published in the Proceedings of the National Academy of Sciences.
The researchers combined cervical cancer cells containing HPV18, a high-risk HPV, with bovine papillomavirus E2 protein. HPV E6 and E7 repression was rapid, they said, and was followed by "profound inhibition of cellular DNA synthesis."
Additionally, Goodwin et al. reported, following this repression, there was post-transcriptional induction of p53 followed by two functional p53-responsive genes, mdm2 and p21. Induction of p105(Rb), p107, and p130 also was noted ...
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Source: HighBeam Research, Cervical Carcinogenesis Curbed by HPV Oncogene Repression.(human...