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Vaccine Found Safe in Early Study.(Brief Article)
2001 JAN 17 - (NewsRx.com & NewsRx.net) -- Johns Hopkins University researchers say early tests of a pancreatic cancer vaccine show it is safe and successful in reaching immune system cells.
A report on the findings was published in the January 2001 issue of the Journal of Clinical Oncology.
The vaccine, tested on 14 patients, uses lab-grown pancreatic cancer cells genetically-modified with the immune-boosting gene GM-CSF.
After surgery to remove the pancreatic cancers, patients received varying doses of the vaccine. Twelve of the 14 then underwent radiation and chemotherapy following the initial vaccination. Six patients received up to three additional monthly vaccinations.
Researchers found that several parts of the immune system were activated in three patients who got the highest doses. These patients remain disease-free more than 30 months after diagnosis. The other 11 patients showed no significant immune response. Side effects included only local skin reactions and redness and itchiness at the vaccine site for several days (J Clin Oncol, 2001;19(1)).
"This study was just a first step, but we are encouraged to find that it is safe and initiates an immune response in certain doses," says Elizabeth Jaffee, MD, associate professor of oncology and lead author of the study.
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