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Memory Cells in Tonsils May Cause Long-Term Infection.(Brief Article)
2001 JAN 10 - (NewsRx.com & NewsRx.net) -- Chronic infection with the Epstein-Barr virus may be mediated, ironically, by white blood cells in the tonsils responsible for the long-term "memory" of the immune system, researchers suggest.
"Epstein-Barr virus (EBV) establishes a life-long persistent infection in most of the human population," explained G.J. Babcock and colleagues at Tufts University. "In the peripheral blood, EBV is restricted to memory B cells that are resting and express limited genetic information."
Writing in the Proceedings of the National Academy of Sciences, Babcock et al. show how the unique genetic expression of tonsillar memory B cells could cause the persistence of EBV infection ("Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors," Proc Nat Acad Sci USA, 2000;97(22):12250-12255).
Memory cells in the tonsils express genes for latent membrane protein 1 and 2a (LMP1 and LMP2a) and for EBV nuclear antigen 1 (EBNA1), but not for EBNA2 or EBNA3s, the researchers reported, a pattern so far considered unique to EBV-related tumors found in Hodgkin's disease and nasopharyngeal cancer.
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Source: HighBeam Research, Memory Cells in Tonsils May Cause Long-Term Infection.(Brief Article)