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Genetic Immunization Using Recombinant Alphavirus Vector of HPV Proteins Could be Therapeutic, Prophylactic.(Brief Article)
2001 JAN 10 - (NewsRx.com & NewsRx.net) -- A recombinant Semliki Forest virus vector expressing human papillomavirus gene products appears to provide effective genetic immunization against cervical cancer in mice - even at relatively low doses.
Researchers in The Netherlands created a recombinant Semliki Forest virus (SFV) vector that expresses the human papillomavirus (HPV) proteins, E6 and E7. Expression of E6 and E7, they explained, is key to the transforming potential of HPV-16 and HPV-18, strains linked to development of cervical cancer via infection of genital epithelial cells.
"Since the expression of E6 and E7 is selectively maintained in premalignant and malignant cervical lesions, these proteins are attractive candidates for immunotherapeutic and prophylactic strategies," wrote T. Daemen and colleagues at the University of Groningen ("Genetic immunization against cervical carcinoma: Induction of cytotoxic T lymphocyte activity with a recombinant alphavirus vector expressing human papillomavirus type 16 E6 and E7," Gene Therapy, 2000;7(21):1859-1866).
The researchers demonstrated that SFV-delivered E6 and E7 proteins were, in fact, expressed in infected cells and reported that in mice, injection with SFV-E6E7 "resulted in an efficient in vivo priming of HPV-specific CTL [cytotoxic T lymphocyte] activity."
"The induced CTL ...
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- Newspaper article from: Vaccine Weekly April 16, 2003 700+ words
...Recombinant Semliki Forest virus expressing a...immunization with recombinant Semliki Forest virus (SFV) expressing the human...immunisation with recombinant Semliki Forest virus expressing a...immunization with recombinant SFV particles encoding...
- Data on semliki forest virus cell biology reported by investigators at...
- Newspaper article from: Virus Weekly September 9, 2008 700+ words
...Apoptosis induced by Semliki Forest virus is RNA replication...The RNA alphavirus Semliki Forest (SFV) triggers apoptosis...Germany report (see also Semliki Forest Virus Cell Biology). "Here, we show that SFV-induced apoptosis...
- Semliki Forest virus-based vaccine effective.
- Newspaper article from: AIDS Weekly February 24, 2003 700+ words
...Hanke and coauthors reported. SFV.HIVA consists of a Semliki Forest virus (SFV) vector carrying a gene coding...reported in this study include: * A Semliki Forest virus vector carrying the HIVA gene (SFV.HIVA) is immunogenic in mice...
- Investigators at University of Oxford have published new data on semliki forest...
- Newspaper article from: Virus Weekly November 25, 2008 700+ words
...member of the Semliki Forest virus (SFV) complex in the...represent a variant of SFV rather than a...report (see also Semliki Forest Virus). "To...clarify whether SFV continues to circulate...Tri virus: a Semliki Forest virus strain from...
- Findings from Wuhan University provide new insights into semliki forest...
- Newspaper article from: Virus Weekly March 31, 2009 700+ words
...Republic of China, "Semliki forest virus (SFV) is a pathogen causing...could specifically target SFV sequence in GFP reporting...effectively suppress SFV replication in luciferase...University (see also Semliki Forest Virus). The researchers...
- Research from University of Edinburgh yields new data on semliki forest virus.
- Newspaper article from: Virus Weekly January 6, 2009 700+ words
...Here we show that Semliki Forest virus (SFV) infection of Aedes...Edinburgh (see also Semliki Forest Virus). The researchers...concluded: "However, SFV infection of mosquito...Molecular Biology (Semliki Forest virus strongly reduces...
- Findings in semliki forest virus reported from University of Helsinki.
- Newspaper article from: Virus Weekly November 25, 2008 700+ words
...ts) mutations in Semliki Forest virus (SFV) were previously...Helsinki (see also Semliki Forest Virus). The researchers...Integrating data from SFV and Sindbis virus...sensitive mutations in Semliki Forest virus nsP1. Journal...
- T cell activity induced by recombinant Semliki Forest virus vaccine.
- Newspaper article from: Vaccine Weekly May 26, 2004 700+ words
...with recombinant Semliki Forest virus. According...with recombinant Semliki Forest virus (rSFV...three different SFV-constructs encoding...presentation after SFV-based immunization...with recombinant Semliki Forest virus: indications...
- Study data from University of Tartu update understanding of semliki forest...
- Newspaper article from: Virus Weekly June 30, 2009 700+ words
...study from Tartu, Estonia, "Semliki Forest virus (SFV) has a positive strand RNA...University of Tartu (see also Semliki Forest Virus). The researchers...competent vectors based on Semliki Forest virus. Virology Journal...
- Study data from Karolinska Institut update knowledge of semliki forest...
- Newspaper article from: Virus Weekly October 28, 2008 700+ words
...domain of glycoprotein E2 precursor in Semliki Forest virus provides a unique contact with...alphaviruses, here represented by Semliki Forest virus, infection requires an acid...Huddinge, Sweden report (see also Semliki Forest Virus). "To reveal how the E3 domain...
Source: HighBeam Research, Genetic Immunization Using Recombinant Alphavirus Vector of HPV...