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Potential Vaccine Prevents Memory Loss in Mice.(Brief Article)
2001 JAN 10 - (NewsRx.com & NewsRx.net) -- Researchers in the University of Toronto's (UT) Faculty of Medicine have discovered that a vaccine may help prevent and treat the disabling memory loss and cognitive impairment (dementia) of Alzheimer's disease.
Alzheimer's disease (AD) occurs when toxic biochemical compounds known as amyloid (beta) peptides accumulate in the brain, forming amyloid plaque deposits and injuring nerve cells, eventually causing dementia. While previous studies have shown that vaccinating transgenic mice with this peptide could remove the amyloid plaques, there was never any evidence of improvement in brain function.
After developing transgenic mice with amyloid plaques and cognitive impairment similar to those found in human Alzheimer's, scientists at UT's Centre for Research in Neurodegenerative Diseases (CRND) determined that immunization with amyloid (beta) peptides blocked both the production of the plaques and learning impairment.
"Not only were we able to clean up the brain tissue, but we also prevented the behavioral consequences of Alzheimer's," said Dr. Peter St. George-Hyslop, director of the CRND and a neurologist at the University Health Network. "Obviously, it is more important that a treatment or prevention in humans be able to block the clinical dementia."
St. George-Hyslop and his colleagues said the amyloid (beta) peptide vaccination is ready to be tested on humans.
"Our results also show that pharmaceutical treatments that are directed ...
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Source: HighBeam Research, Potential Vaccine Prevents Memory Loss in Mice.(Brief Article)