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Respiratory Syncytial Virus Antigen Produced in Tobacco.(Brief Article)

Vaccine Weekly

| January 10, 2001 | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 JAN 10 - (NewsRx.com & NewsRx.net) -- Researchers at Thomas Jefferson University, Philadelphia, Pennsylvania, have produced human respiratory virus vaccine antigen in tobacco plants.

"Human respiratory syncytial virus (RSV) is the primary cause of respiratory infection in infants worldwide. Currently there is no available vaccine, although studies in animal models have demonstrated protective immunity induced by an epitope of the RSV G-protein representing amino acids 174-187," wrote H. Belanger and colleagues ("Human respiratory syncytial virus vaccine antigen produced in plants," FASEB Journal, 2000;14(14):2323-2328).

"Two peptides containing amino acids 174-187 of the G-protein of the human RSV A2 strain (NF1-RSV/172-187 and NF2-RSV/170-191) were separately engineered as translational fusions with the alfalfa mosaic virus coat protein and individually expressed in Nicotiana tabacum cv. Samsun NN plants through virus ...

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Source: HighBeam Research, Respiratory Syncytial Virus Antigen Produced in Tobacco.(Brief...

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