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Blocking Hairpin Formation Can Inhibit RSV.(Brief Article)
2001 JAN 10 - (NewsRx.com & NewsRx.net) -- Blocking hairpin formation of the human respiratory syncytial virus (HRSV)-F protein inhibits entry of the virus and thus suggests an approach for development of a vaccine or chemoprophylaxis against the virus, say Massachusetts Institute of Technology researchers.
"Two heptad-repeat regions within the HRSV F sequence were predicted by the computer program learncoil-vmf," said X. Zhao and colleagues, writing in the Proceedings of the National Academy of Sciences - USA.
"These regions are thought to form trimers of hairpin-like structures, similar to those found in the fusion proteins of several enveloped viruses. The hairpin structure likely brings the viral and cellular membranes into close apposition, thereby facilitating membrane fusion and subsequent viral entry."
Zhao et al. studied the structure of the HRSV fusion protein core. They crystallized the HRSV fusion protein complex and visualized the structure via X-ray at 2.3-Angstrom resolution.
They found that the peptides from the heptad-repeat region of the N-terminal segment of the fusion protein, which they called HR-N, "form a three-stranded, central coiled coil," while the ...
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Source: HighBeam Research, Blocking Hairpin Formation Can Inhibit RSV.(Brief Article)