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Combined Intranasal and Intramuscular Immunization Boosts Anti-Flu Response.(Brief Article)
2001 JAN 10 - (NewsRx.com & NewsRx.net) -- A new study suggests using a combined strategy of intranasal and intramuscular immunization with either live or inactivated influenza virus enhances the immune response to flu infection.
Baylor College of Medicine researchers conducted two double-blind, placebo-controlled trials, administering in one a monovalent, live attenuated, cold-adapted recombinant (CR) or inactivated influenza virus (MIV) vaccine, and in the other, an intramuscular vaccine with MIV.
W.A. Keitel and colleagues reported their results in the December 2000 issue of the Journal of Infectious Disease ("Immunization against influenza: Comparison of various topical and parenteral regimens containing inactivated and/or live attenuated vaccines in healthy adults," J Infect Dis, December 2000;183(2)).
"Healthy susceptible adults were assigned randomly to receive 10(7.1) TCID[50] of CR (A/H1N1 or A/H3N2), homologous MIV (15 (micro)g), or placebo intranasal and ...
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