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Enviromental, Genetic Factors May Play Causal Role in Preeclampsia.
WASHINGTON -- Several genes and environmental factors appear to influence maternal predisposition for developing preeclampsia, said Dr. James J. Walker at the FIGO World Congress of Gynecology and Obstetrics.
Preeclampsia is increasingly thought to be a potential familial disease, noted Dr. Walker, who summarized the results of recent studies exploring the genetics of preeclampsia at the meeting, which was also sponsored by the American College of Obstetricians and Gynecologists.
A 49-year follow-up study of the genetics of hypertension in pregnancy found the disorder to be "highly heritable." Researchers found preeclampsia in 37% of 147 sisters, 25% of 248 daughters, and 16% of 74 granddaughters of eclamptic patients studied 49 years previously (Br. J. Obstet. Gynaecol. 93[93:898-908, 1986).
The wide variation in presentation and progression of the disease suggests the existence of genetic factors that modulate the process, he said. Studies conducted to date have revealed a number of modulator genes, including angiotensinogen, tumor necrosis factor-alpha, glutathione S-transferase P1, lipoprotein lipase, HLA-G, methylenetetrahydrofolate reductase, factor V Leiden mutation, plasminogen activator inhibitor-1, and ...
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...been related to environmental and/or genetic factors. Of interest are genes associated...University of Newcastle (see also Preeclampsia). The researchers concluded: "This...Eclampsia, Haemostasis, Obstetrics, Preeclampsia, Prothrombin, Thrombolytic, Thrombosis...
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...From AScribe) MINNEAPOLIS -- The Preeclampsia Foundation announced today that Dr...a lifetime of research dedicated to preeclampsia (see bio, below). His investigation...important contributor to the development of preeclampsia as well as his work with Dr. Carl...
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...that place women at greater risk of preeclampsia, researchers have crossed at least...miscarriage regarding their risks of preeclampsia in subsequent pregnancies. There were...possibly play a role in the development of preeclampsia, including abortion, medical history...
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...of women who have had an episode of preeclampsia will develop it in a subsequent pregnancy...significant a risk factor for future preeclampsia as chronic hypertension, renal disease...The earlier in the first gestation preeclampsia developed, the higher the risk of...
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Preeclampsia and eclampsia were the third leading...000 live births were attributable to preeclampsia or eclampsia during this time period...other causes. The risk of death from preeclampsia or eclampsia was highest between 20...
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Byline: Preeclampsia Foundation MINNEAPOLIS, Sept. 20 (AScribe Newswire) -- Leslie Weeks, Preeclampsia Board Chair and Steve and Jennifer...this seriously dangerous variant of preeclampsia. Bohach continued, "Jennifer and...
Source: HighBeam Research, Enviromental, Genetic Factors May Play Causal Role in Preeclampsia.