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Screen for Genetic Mutations In Women With a History Of Late Pregnancy Loss.

OB GYN News

| November 15, 2000 | DEMOTT, KATHRYN | COPYRIGHT 2000 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Women with a history of late pregnancy loss should be screened for mutations in the genes that code for the coagulation factors prothrombin and factor V Leiden, according to Italian researchers.

Women with a history of late pregnancy loss are three times more likely to carry such genetic mutations, the investigators said. Still, the jury is out on whether the benefits of anticoagulation therapy during subsequent pregnancies would override the bleeding and osteopenic risks associated with such therapy, said Dr. Ida Martinelli of the Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital, Milan, and associates.

In their case-control study, 11 of 67 (16%) women with a first episode of unexplained late fetal loss and 13 of 232 (6%) control women with a history of only normal pregnancies had the prothrombin or factor V mutations (N. Engl. J. Med. 343[14]:1015-18, 2000).

The relative risk of late fetal loss in carriers of factor V or prothrombin mutations was 3.2 and 3.3, respectively, compared with ...

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