Simulated Moving Bed Technique.

Simulated moving bed (SMB) chromatography techniques are suited to commercial size separation processes. In continuous moving bed chromatography, the stationary phase moves relative to the feed and mobile phase inputs and the extract and raffinate outputs. Because of the difficulty in using a moving stationary phase in chromatographic separations, its simulation is favored in practice. Incremental positional changes of the input and output streams, relative to a static stationary phase, is carried out at regular intervals.

Even though some separations are conducted using SMB processes operating at low capacity factors, few separations are carried out using weakly …