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Massachusetts Biotech Firm Expects Human Trials for Anti-cancer Protein.
Knight Ridder/Tribune Business News
Sep. 17 -- A potent new cancer-fighting protein discovered in the Boston lab of Dr. Judah Folkman can be made by slightly altering a drug that's already on the market, and therefore could enter human trials as early as next year, say officials of a Framingham biotech firm.
The new protein seems to be at least as powerful as endostatin, the widely publicized tumor-starving drug also discovered in Folkman's lab. Endostatin is about to enter its first, long-awaited human tests in Boston.
Called antiangiogenic antithrombin, or aaAT, the new protein is being described publicly for the first time today, in the current issue of the journal Science.
Genzyme Molecular Oncology in Framingham, which has licensed ...
- HORMONES AND CYTOKINES: Antithrombin III Prevents Blood Vessel Formation.
- Newspaper article from: Applied Genetics News October 19, 1999 700+ words
...colleagues in Judah Folkman's laboratory...of the serpin antithrombin III," appears in...progress, using antithrombin III in conjunction...quantities of antithrombin III from the milk...expertise of Drs. Folkman and O'Reilly...
- High-dose antithrombin III in severe sepsis. A randomized controlled trial....
- Magazine article from: Emergency Medicine Journal Wyatt, Jonathan March 1, 2002 700+ words
...set out to determine if high dose antithrombin III (administered within six hours of...to receive 30 000 IU of intravenous antithrombin III over four days or a placebo of 1...Overall mortality at 28 days in the antithrombin III treatment group was 38.9% compared...
- ANTITHROMBIN-III TEST.
- CareNotes December 1, 2001 700+ words
ANTITHROMBIN-III TEST GENERAL INFORMATION: What is it? Antithrombin-III (an-ti-throm-bun) also called AT-III is a naturally occurring anticoagulant (an-ti ko-ag-u-lunt) protein found in the blood. An anticoagulant keeps...
- Genzyme Transgenics Receives United States Patent for Transgenic Production of...
- Press release article from: PR Newswire December 1, 1998 700+ words
...granted U.S. Patent 5,843,705, "Transgenically Produced Antithrombin III" by the United States Patent and Trademark Office. The patent covers recombinant human antithrombin III (rh AT III) produced in the milk of transgenic goats. Currently...
- Antithrombin-III test.
- CareNotes May 1, 2006 700+ words
GENERAL INFORMATION: What is it? Antithrombin-III (an-tee-THROM-bin) is also called AT-III. It is an anticoagulant (an-tee-ko-AG-u-lant) protein that is naturally...
- Antithrombin-III test.(blood test that measures the amount of AT-III in your...
- CareNotes August 1, 2006 700+ words
GENERAL INFORMATION: What is it? Antithrombin-III (an-tee-THROM-bin) is also called AT-III. It is an anticoagulant (an-tee-ko-AG-u-lant) protein that is naturally...
- GTC Biotherapeutics Completes Enrollment in European Efficacy Study;...
- Press release article from: PR Newswire December 17, 2003 700+ words
...Biotherapeutics, Inc. (Nasdaq: GTCB; "GTC") announced today that enrollment into the efficacy study for recombinant human antithrombin III (rhATIII) has been completed. The results of the efficacy study will be included in a filing requesting marketing authorization...
- Genzyme Transgenics Completes Successful Phase II Clinical Trial for...
- Press release article from: PR Newswire September 4, 1997 700+ words
...announced today that it has successfully completed a phase II clinical trial for its lead product candidate, recombinant human antithrombin III (rhATIII), which is produced in the milk of transgenic goats. Analysis of the results of the trial, which involved...
- Preclinical Study Published in Today's Issue of Science Cites Potency of...
- Press release article from: PR Newswire September 16, 1999 700+ words
...research fellow in Dr. Judah Folkman's laboratory at Children's Hospital, Dr. Folkman, director of the Surgical Research...cleaved conformation of the serpin antithrombin III," states results of Drs. Folkman and O'Reilly's preclinical...
- Hype, Hope, Cancer.(Dr. Jodah Folkman's cancer research)(Brief Article)
- Magazine article from: Newsweek Kalb, Claudia December 28, 1998 700+ words
Medicine: Dr. Judah Folkman lit a firestorm when his research findings...Biblical central figure: Moses Judah Folkman, the perfect bearer for a miracle...The New York Times chose to trumpet Folkman's discoveries on its front page...
Source: HighBeam Research, Massachusetts Biotech Firm Expects Human Trials for Anti-cancer...