Bio-Rad Laboratories Inc release: published study validates new protein enrichment approach for low-abundance biomarker detection.

University of Minnesota researchers found that Bio-Rad Laboratories' ProteoMiner protein enrichment kit enhanced identification of changes to low-abundance proteins and detection of post-translationally modified (PTM) proteins in human saliva. These findings offer promise for improving differential proteomic analyses and biomarker studies aimed at identifying disease-specific proteins and their PTM variants in various types of biological samples and fluids. The study was published in the 4 Mar 2011, issue of the Journal of Proteome Research. Even when highly sensitive mass spectrometers are used to analyze complex biological samples and bodily fluids, high-abundance proteins obscure the …