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Long-term fluoxetine for relapse prevention of bipolar depression.(News Notes)(Report)(Brief article)
Long-term fluoxetine monotherapy may provide superior relapse prevention, compared with lithium, for patients with bipolar II disorder recovering from a major depressive episode. The finding is from a clinical trial of patients with bipolar II disorder who recovered from a major depressive episode during open-label fluoxetine monotherapy and were subsequently randomized to fluoxetine 10-40 mg/day, lithium 300-1,200 mg/day, or placebo, under double-blind conditions for 50 weeks. Time to a full syndromal depressive relapse or recurrence was significantly longer …
