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Research conducted at Erasmus University has provided new information about aspergillosis.
"At present, voriconazole (VOR) is the drug of first choice for treating invasive pulmonary aspergillosis (IPA). However, particularly in advanced stages of disease and in the severely immunocompromised host, the mortality remains substantial," researchers in Netherlands report (see also Aspergillosis).
"The combination of VOR with an echinocandin may improve the therapeutic outcome. We investigate here whether combining VOR and anidulafungin (ANI) in advanced IPA in transiently neutropenic rats results in a higher therapeutic efficacy. Since VOR is metabolized more rapidly in rodents than in humans, dosage adjustment for VOR is necessary to obtain an area under the plasma concentration-time curve (AUC) in rodents that is equivalent to that of humans. In this study, the pharmacokinetics of VOR and ANI in rats were elucidated, and dosage schedules were applied that produced AUCs similar to those of humans. The developed dose schedules were well tolerated by the rats, without effects on renal and hepatic functions. VOR showed excellent efficacy in early IPA (100% rat survival). In advanced IPA, VOR was less efficacious (50% rat survival), whereas a significant decrease in galactomannan concentrations in lungs and sera was found in surviving rats. ANI administered in advanced IPA resulted in 22% rat survival, and the serum concentrations of fungal galactomannan were slightly but not significantly decreased. The addition of ANI to VOR did not result in significantly increased therapeutic efficacy in advanced ...
- The Financial Times Ranks RSM Erasmus University Executive Education &...
- Press release article from: PR Newswire Europe May 15, 2006 700+ words
...education programmes. It ranks RSM Erasmus University Executive Education & Development...About Executive Education at RSM Erasmus University: RSM Executive Education &...clients. More information on RSM Erasmus University RSM Executive Education & Development...
- CMG and Erasmus University continue ASP investigation over the net Provisional...
- Press release article from: M2 Presswire January 24, 2001 700+ words
...24 January 2001-CMG: CMG and Erasmus University continue ASP investigation over the...by CMG together with Rotterdam's Erasmus University and the universities of Oxford...well as part-time professor at Erasmus University and the University of Melbourne...
- Investigators at Erasmus University release new data on surgery.
- Newspaper article from: Biotech Week December 10, 2008 700+ words
...tested using data from the main OR of Erasmus University Medical Center (Erasmus MC). Two...M. Vanoostrum and colleagues, Erasmus University. The researchers concluded: "Our...information, contact J.M. Vanoostrum, Erasmus University, Medical Center, Dept. of Operating...
- Studies conducted at Erasmus University on neoplasms recently published.(Report)
- Newspaper article from: Cancer Weekly August 25, 2009 700+ words
...of the Department of Pathology, Erasmus University Medical Center, were retrospectively...wrote J. Snaathorst and colleagues, Erasmus University (see also Neoplasms). The researchers...information, contact J. Snaathorst, Erasmus University, Medical Center, Dept. of Oral...
- New findings from Erasmus University, Medical Department in the area of...
- Magazine article from: Women's Health Weekly January 29, 2009 700+ words
...prospective single center study (Erasmus University Medical Center, Rotterdam, The...N. Vanheesch and colleagues, Erasmus University, Medical Department (see also Chromosomal...information, contact P.N. Vanheesch, Erasmus University, Medical Center Rotterdam, Division...
- Erasmus University publishes research in instructional science.
- Newspaper article from: Science Letter October 28, 2008 700+ words
...M.M. Loyens and colleagues, Erasmus University (see also Instructional Science...information, contact S.M.M. Loyens, Erasmus University, Dept. of Psychology, Burg Oudlaan...Psychology, Mental Health, Education, Erasmus University. This article was prepared by Science...
- Erasmus University reports research in heart disease.
- Newspaper article from: Heart Disease Weekly January 25, 2009 700+ words
...wrote J. Versmissen and colleagues, Erasmus University (see also Heart Disease). The...contact E.J.G. Sijbrands, Erasmus University, Medical Center, Dept. of Internal...Coronary Heart Disease, Heart Disease, Erasmus University. This article was prepared by Heart...
- Erasmus University publishes research in cardiology.
- Newspaper article from: Cardiovascular Week February 23, 2009 700+ words
...L. Geleijnse and colleagues, Erasmus University (see also Cardiology). The researchers...information, contact M.L. Geleijnse, Erasmus University, Thoraxctr, Erasmus Med Center...Reactions, Cardiology, Cardiovascular, Erasmus University. This article was prepared by Cardiovascular...
