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Study data from University of Limoges update understanding of african trypanosomiasis.
"To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis. We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic)," scientists in Limoges, France report (see also African Trypanosomiasis).
"Results were compared to standard stage determination markers and IgM intrathecal synthesis. CXCL-13 levels in patients' sera had a median value of 386.6 pg/ml and increased levels were associated with presence of trypanosomes in the CSF but not with other stage markers. CXCL-13 levels in patients' CSF had a median value of 80.9 pg/ml and increased levels were associated with all standard stage determination markers and IgM intrathecal synthesis. CXCL-13 levels in CSF increased significantly during the course of HAT. Hence the value of CXCL-13 for diagnosis, follow-up or as a marker of disease severity should be tested in a well-defined cohort study.DEterminer le role du chemokine CXCL-13 des cellules B, qui pourrait initier le mouvement des cellules B et la production d'IgM, dans le diagnostic de la mEningo-encEphalite de la trypanosomiase humaine africaine (THA). Nous avons dEterminE les taux de CXCL-13 par la technique ELISA sur des Echantillons appariEs de sErum et de LCR de 26 patients de l'Angola et de 16 controles (6 endEmiques et 10 non endEmiques). Les rEsultats ont EtE comparEs a la dEtermination standard des marqueurs de stade et a la synthese intrathEcale d'IgM. Les taux de CXCL-13 dans les sera des patients avaient une valeur mEdiane de 386,6 pg/mL et des taux ElevEs Etaient associEs a la prEsence de trypanosomes dans le LCR, mais pas avec d'autres marqueurs de stade. Les taux de CXCL-13 dans le LCR des patients avaient une valeur mEdiane de 80,9 pg/mL et des taux ElevEs Etaient associEs a tous ...
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Source: HighBeam Research, Study data from University of Limoges update understanding of african...