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Immune system has legs.(HEADLINE SCIENCE)
How do white blood cells get to the site of infection or injury? They must crawl swiftly along the lining of the blood vessel--gripping it tightly to avoid being swept away in the blood flow--all the while searching for temporary "road signs" made of special adhesion molecules that let them know where to cross the blood vessel barrier so they can get to the damaged tissue.
Current opinion maintains that immune cells advance like inchworms, but new findings show that the rapid movement of the white blood cells is more like that of millipedes. Rather than sticking front and back, folding and extending to push itself forward, the cell creates numerous tiny "legs" no more than a micron in length--adhesion points, rich in adhesion molecules (named LFA-1) that bind to partner adhesion molecules present on the surface of the blood vessels. Tens of these legs attach and detach in sequence within seconds--allowing them to move rapidly while keeping a good grip on the vessels' sides.
Images produced by transmission and scanning electron ...
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