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Research conducted at University of Nevada, Medical Department has updated our knowledge about life sciences.
"Meiotic sex chromosome inactivation (MSCI) during spermatogenesis is characterized by transcriptional silencing of genes on both the X and Y chromosomes in mid-to-late pachytene spermatocytes(1). MSCI is believed to result from meiotic silencing of unpaired DNA because the X and Y chromosomes remain largely unpaired throughout first meiotic prophase(2)," scientists in the United States report (see also Life Sciences).
"However, unlike X-chromosome inactivation in female embryonic cells, where 25-30% of X-linked structural genes have been reported to escape inactivation(3), previous microarray(4)- and RT-PCR5-based studies of expression of > 364 X-linked mRNA-encoding genes during spermatogenesis have failed to reveal any X-linked gene that escapes the silencing effects of MSCI in primary spermatocytes. Here we show that many X-linked miRNAs are transcribed and processed in pachytene spermatocytes," wrote R. Song and colleagues, University of Nevada, Medical Department.
The researchers concluded: "This unprecedented escape from MSCI by these X-linked miRNAs suggests that they may participate in ...
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- Research from University of Szeged, Medical Department in life sciences...
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Source: HighBeam Research, Research conducted at University of Nevada, Medical Department has...