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New cytokines data have been reported by researchers at University of Toronto.(Report)
According to a study from Toronto, Canada, "The objective of the study was to determine the effect of fetal sex on the output of cytokines and prostaglandin-regulating enzymes in lipopolysaccharide (LPS) and probiotic lactobacilli-treated placental trophoblast cells. We examined the effect of LPS and Lactobacillus rhamnosus GR-1 supernatant in placental trophoblast cells on tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, and IL-10 using enzyme-linked immunosorbent assay and on prostaglandin-endoperoxide synthase 2 (PTGS2), 15-hydroxy prostaglandin dehydrogenase (PGDH), and toll-like receptor-4 (TLR-4) using Western blotting."
"Comparisons were performed using one-way analysis of variance and Student t test. LPS increased the output of TNF-alpha, IL-10, and PTGS2 with a greater response in male placentae. L rhamnosus GR-1 supernatant inhibited the LPS-stimulated TNF-alpha and increased IL-10. It also up- regulated expression of PGDH in female placentae and partially reduced the LPS-stimulated PTGS2 in male placentae. There was no change in IL-1 beta. Expression of TLR-4 was greater in placentae of male fetuses," wrote M. Yeganegi and colleagues, University of Toronto (see also Cytokines).
The researchers concluded: "These findings suggest an underlying mechanism for the sex difference in the ...
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Source: HighBeam Research, New cytokines data have been reported by researchers at University of...