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Studies from University of Pennsylvania, Medical Department have provided new information about chlamydia.
"We sought to determine whether Chlamydia pneumoniae impairs invasive trophoblast function and is associated with preeclampsia. We conducted cell viability and invasion assays using primary extravillous trophoblast cells isolated from first-trimester placentas," scientists in the United States report (see also Chlamydia).
"We performed a case-control study to identify C pneumoniae in trophoblast cells dissected by laser capture microscopy from placentas in women with severe preeclampsia and control subjects who delivered at term. Trophoblast cell viability and invasion through extracellular matrices were decreased after infection with C pneumoniae (both P
The researchers concluded: "Further investigation of the mechanisms by which C pneumoniae induces trophoblast dysfunction, and the identification of therapies to prevent adverse outcomes attributed to trophoblast dysfunction, are warranted."
Gomez and colleagues published their study in American Journal of Obstetrics and Gynecology (Trophoblast infection with Chlamydia pneumoniae and adverse pregnancy outcomes associated with placental dysfunction. American Journal of Obstetrics and Gynecology, 2009;200(5):E1).
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