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Section II: Chemistry Science Center.

Georgia Journal of Science

| March 22, 2009 | COPYRIGHT 2009 Georgia Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

12:00 MECHANISTIC INSIGHT OF FRAGMENTATION CHARACTERISTICS OF MACROLIDE ANTIBIOTICS, Victor Ibeanusi and Yassin Jeilani, Spelman College, Environmental Science and Studies. Macrolide antibiotics are composed of a large ring (14 to 16 carbons) on which several sugars are attached, some of these are amino sugars with diethylamino group. Mass spectrometric characterization of macrolide antibiotics has been a challenge because of low number of characteristic fragments in their collision induced dissociation. Tandem mass spectrometric fragmentation of these antibiotics show two types of dissociations: a) cleavage of glycosidic linkages attaching the sugars to the macrolide ring ...

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