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Researchers from University of Michigan, Medical Department describe findings in ischemia.

Women's Health Weekly

| May 07, 2009 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

"We hypothesized that pretreatment with docosahexaenoic acid (DHA), a potentially neuroprotective polyunsaturated fatty acid, would improve function and reduce brain damage in a rat model of perinatal hypoxia-ischemia. Seven-day-old rats were divided into 3 treatment groups that received intraperitoneal injections of DHA 1, 2.5, or 5 mg/kg as DHA-albumin complex and 3 controls that received 25% albumin, saline, or no injection," scientists in the United States report (see also Ischemia).

"Subsequently, rats underwent right carotid ligation followed by 90 minutes of 8% oxygen. Rats underwent sensorimotor testing (vibrissae-stimulated forepaw placing) and morphometric assessment of right-sided tissue loss on postnatal day 14. DHA pretreatment improved forepaw placing response to near-normal levels (9.5 +/- 0.9 treatment vs 7.1 +/- 2.2 controls; normal = 10; P

The researchers concluded: "DHA pretreatment improves functional outcome and reduces volume loss after hypoxia-ischemia in neonatal rats."

Berman and colleagues published their study in American Journal of Obstetrics and Gynecology (Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal ...

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