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"The purpose of this study was to evaluate the diagnostic accuracies of 2 free thyroxine immunoassays during pregnancy. Serum was collected from healthy, thyroid peroxidase antibody-negative women during each trimester and nonpregnant controls," investigators in the United States report (see also Immunoassay).
"Thyrotropin, total T4 (TT4), free T4 index (FT4I), and 2 different FT4 immunoassays were studied. As expected, TT4 was elevated in all 3 trimesters compared to controls (P
The researchers concluded: "TT4 and the FT4I retained an appropriate inverse relationship with TSH throughout pregnancy and appear to provide a more reliable free T4 estimate."
Lee and colleagues published their study in American Journal of Obstetrics and Gynecology (Free T4 immunoassays are flawed during pregnancy. American Journal of Obstetrics and Gynecology, 2009;200(3):E1).
For additional information, contact R.H. Lee, Los Angeles County University So California, Medical CenterWomen's & Children's ...
Source: HighBeam Research, Studies from R.H. Lee and colleagues yield new information about...