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Research on Down syndrome reported by scientists at University of Bologna.
"Mental retardation, the hallmark of Down syndrome (DS), has been attributed to the reduced number of neurons populating the DS brain. The Ts65Dn mouse model of DS displays several anomalies analogous to those in individuals with DS, including neurogenesis impairment," investigators in Bologna, Italy report (see also Down Syndrome).
"The goal of the current study was to determine whether cell cycle alterations underlie neurogenesis impairment in the cerebellum of the Ts65Dn mouse and to identify the molecular mechanisms responsible for this defect. In neonatal (2-day old) Ts65Dn mice, cerebellar granule cell precursors exhibited a reduced proliferation rate (-40%) and a notable elongation (+45%) of the cell cycle. Alteration of cell cycle rate was due to elongation of the G(2) and G(1) phases. Microarray screening of cell cycle regulatory genes showed that Ts65Dn mice had a decreased expression of Cyclin B1 and Skp2, two key regulators of G(2)/M and G(1)/S transition. Results point at cell cycle elongation as major determinant of neurogenesis reduction in the cerebellum of Ts65Dn mice and suggest that this defect is specifically linked to an altered expression of two cell-cycle regulatory genes, Cyclin B1 and Skp2," wrote A. Contestabile and colleagues, ...
- Data from University of Bologna provide new insights into enzyme research.
- Newspaper article from: Proteomics Weekly June 29, 2009 700+ words
...thoroughly in the G(1) cell cycle phase. However...scientists in Bologna, Italy report...1 in G(2)/M cell cycle progression and...and G(2)/M cell cycle progression. Faseb...University of Bologna, Cellular Signaling...
- Reports outline breast cancer study findings from University of Bologna.
- Newspaper article from: Anti-Infectives Week July 20, 2009 700+ words
...glycoprotein cleavage. Cell Cycle, 2009;8(9):1421...Martelli, University of Bologna, Dipartimento Science...Irnerio 48, I-40126 Bologna, Italy. The publisher of the journal Cell Cycle can be contacted at...Keywords: Italy, Bologna, Apoptosis, Breast...
- New genetics research from University of Bologna outlined.
- Newspaper article from: Life Science Weekly February 24, 2009 700+ words
...process," investigators in Bologna, Italy report (see also Genetics...follicle cells Undergo the mitotic cell cycle, and at midoogenesis when...colleagues, University of Bologna. The researchers concluded...Cavaliere, University of Bologna, Dipartimento Biology Evoluzionist...
- Researchers from University of Bologna detail new studies and findings in the...
- Newspaper article from: Heart Disease Weekly April 12, 2009 700+ words
...peripheral tissues," scientists in Bologna, Italy report (see also Cell...impaired. While length of the cell cycle was similar in fibroblasts...colleagues, University of Bologna. The researchers concluded...Contestabile, University of Bologna, Dept. of Human and General...
- Study findings from University of Bologna broaden understanding of drug...
- Newspaper article from: Biotech Week September 3, 2008 700+ words
...with the G(1) phase of the cell cycle, a phase usually not affected...colleagues, University of Bologna. The researchers concluded...contacting A. Bisi, University of Bologna, Dipartimento Science Farmaceut, Via Belmeloro 6, I-40126 Bologna, Italy. The publisher of...
- Cell Cycle Regulation, Checkpoints, and Cancer.
- Newspaper article from: Cancer Research Alert March 1, 2000 700+ words
Cell Cycle Regulation, Checkpoints, and Cancer...MD, and Daniel L. Stoler, PhD The cell cycle is the basic process by which cells proliferate...Nonproliferating cells may leave the cell cycle and enter G0, a resting phase, or may...
- Cell Cycle
- Reference information from: Biology Raymond, Wendy E. January 1, 2002 700+ words
Cell Cycle The cell cycle is the ordered series of events required for the faithful duplication...eukaryotic cells into two genetically identical daughter cells. In a cell cycle, precise replication of deoxyribonucleic acid (DNA) duplicates...
- Guava Technologies Introduces the Guava Cell Cycle Assay: An All-in-One...
- Press release article from: Business Wire November 8, 2004 700+ words
...Discovery and Cell Health Profiling Cell cycle analysis just became easier than ever, thanks to the new Cell Cycle assay from Guava Technologies, Inc...cell fixation. Moreover, the Guava Cell Cycle assay provides detailed protocols for...
