New cervical cancer screening data have been reported by researchers at University of Pittsburgh.

According to a study from the United States, " To determine the incidence of clinically significant lesions on subsequent histologic follow-up in high-risk, predominantly minority patients with atypical glandular cells (AGC). Design A retrospective study was done on conventional Pap smears diagnosed as A GC of endocervical origin (AGC-EC), AGC of endometrial origin (AGC-EM) and A GC riot otherwise specified (AGC-NOS) between January 1, 2003, and December 31, 2005."

"Histologic diagnoses were correlated with cytologic diagnoses. Confirmed AGC cases were divided into 4 categories: 187 AGC-NOS, 169 AGC-EC, 68 AGC and atypical squamous cells of undetermined significance (ASCUS) and 36 AGC-EM. A total of 105 patients (22.8%) had significant precancerous (cervical intra-epithelial neoplasia [CIN] 213, adenocarcinoma in situ [AIS]) or malignant (carcinoma) histologic outcomes. CIN 213 was the most common significant histologic outcome in women with AGC and ASCUS and patients <35 years with AGC. Endometrial neoplasia was the most common significant outcome in women with AGC-NOS and AGC-EM Pap results and in AGC patients>= 35. In women with AGC-EC Pap results, glandular cervical neoplasia occurred in 8.3% and CIN 2/3 in 5.9% of follow-up biopsies. AGC subtype and age significantly affect the probability of precancerous and malignant follow-up findings and anatomic site of neoplastic lesions," wrote C.Q. Zhao and colleagues, University of Pittsburgh (see also Cervical Cancer Screening).

The researchers concluded: "Access to ...