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Metabolic syndrome blunts aspirin's antiplatelet activity.(CLINICAL ROUNDS)
New Orleans -- Apparently healthy people with a family history of coronary artery disease who also had metabolic syndrome showed elevated platelet aggregation and reduced platelet responsiveness to aspirin in a study of more than 2,000 people.
These findings suggest that "low-dose aspirin therapy alone may not be sufficient to provide optimal antiplatelet protection" in people with metabolic syndrome and an increased risk for coronary artery disease, Dhananjay Vaidya, Ph.D., reported in a poster at the annual scientific sessions of the American Heart Association.
The link between metabolic syndrome and aspirin resistance in platelets was examined because metabolic syndrome is known to be proinflammatory and prothrombotic, Dr. Vaidya said in the poster.
The study by Dr. Vaidya and associates involved 2,088 apparently healthy siblings, sibling offspring, and coparents of the sibling offspring of more than 500 patients who were younger than 60 years and who were hospitalized for coronary artery disease.
The average age of the relatives was about 44 years, and about 58% were women. The group included 591 people (28%) who met the criteria for metabolic syndrome of the Adult Treatment Panel III guidelines of the US. National Cholesterol Education Program; the remaining ...
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Source: HighBeam Research, Metabolic syndrome blunts aspirin's antiplatelet activity.(CLINICAL...