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SAN FRANCISCO -- There is no reason to be hesitant in prescribing topical retinoids to women with acne, according to Dr. Hilary E. Baldwin.
While the teratogenic potential of oral isotretinoin is well known, topical retinoids appear to be safe for use in women of childbearing potential, said Dr. Baldwin of the State University of New York, Brooklyn.
According to data from Allergan Inc., which makes Tazorac (tazarotene gel), the normal, endogenous plasma level of retinoids is 6.6 ng/mL. These retinoids come from food sources such as carrots, red peppers, sweet potatoes, and fish, she said at a meeting sponsored by Skin Disease Education Foundation. Oral isotretinoin raises this level to 862 ng/mL, according to the Accutane package insert. In contrast, tretinoin 0.1% cream raises the ...