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Research on hormones described by scientists at Laval University.
"Blouin K, Nadeau M, Mailloux J, Daris M, Lebel S, Luu-The V, Tchernof A. Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis. Am J Physiol Endocrinol Metab 296: E244-E255, 2009," scientists in Canada report (see also Hormones).
"First published November 4, 2008; doi: 10.1152/ajpendo.00039.2008.-The objective was to examine pathways of androgen metabolism in abdominal adipose tissue in women. Abdominal subcutaneous (SC) and omental (OM) adipose tissue samples were surgically obtained in women. Total RNA was isolated from whole adipose tissue samples and from primary preadipocyte cultures before and after induction of differentiation. Expression levels of several steroid-converting enzyme transcripts were examined by real-time RT-PCR. Androgen conversion rates were also measured. We found higher expression levels in SC compared with OM adipose tissue for type 1 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD-1; P
The researchers concluded: "Higher mRNA levels of enzymes synthesizing and inactivating androgens are found in differentiated adipocytes, consistent with higher androgen-processing rates in these cells. Glucocorticoid-induced androgen inactivation may locally modulate the exposure of adipose cells to active androgens."
Blouin and colleagues published their study in American Journal of Physiology - Endocrinology and Metabolism (Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis. American Journal of Physiology - Endocrinology and Metabolism, 2009;296(2):E244-E255).
For additional information, contact A. Tchernof, Laval University, Medical Research Center, Molecular Endocrinol & Oncology ...
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