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Research on hormones described by L. Mcrobb and colleagues.(Report)
"Arterial calcification has prognostic significance for cardiovascular outcomes, but its pathogenesis remains unclear. Calcification increases with age, but its prevalence in men suggests hormonal influence," scientists writing in the journal Endocrinology report (see also Hormones).
"In this study we analyzed the effect of exogenous androgens on calcification of advanced atherosclerotic lesions in the arterial tree of gonadally intact 34-wk-old male and female apolipoprotein E-null mice. Testosterone (T) increased calcification 3- to 4-fold (P
The researchers concluded: "We demonstrate a novel direct link between vascular calcification and the major male hormone, T, uncoupled from conventional relationships with plaque growth and lipid levels. (Endocrinology 150: 841-848, 2009)'."
Mcrobb and colleagues published their study in Endocrinology (Androgen-Induced Progression of Arterial Calcification in Apolipoprotein E-Null Mice Is Uncoupled from Plaque Growth and Lipid Levels. Endocrinology, 2009;150(2):841-848).
Additional information can be obtained by contacting A.K. Heather, Heart Research Institute, 114 Pyrmont Bridge Rd., Camperdown, NSW 2050, Australia.
The publisher of the journal Endocrinology can be contacted at: Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA.
Keywords: Australia, Camperdown, Angiology, Atherosclerosis, Cardiology, Cardiovascular, Drugs, Endocrinology, Estrogen, Hormones, Innominate Artery, ...
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Source: HighBeam Research, Research on hormones described by L. Mcrobb and colleagues.(Report)