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Research conducted at Central South University has provided new information about DNA research.(Report)
In this recent report published in the journal Pharmacogenomics, researchers in Changsha, People's Republic of China conducted a study "To investigate the correlation between the methylation status in the MDR1 promoter region and the MDR1 genetic polymorphism. A total of 194 unrelated subjects (105 men and 89 women) with a median age of 26 years were enrolled in this study."
"DNA was extracted and PCR-RFLP was performed for C1236T, C3435T and G2677T/A polymorphism genotyping. The combined bisulfite restriction analysis (COBRA) method was also performed to determine DNA methylation levels in the MDR1 promoter region. Genotype frequencies for the variants SNPs were assessed for deviation from Hardy-Weinberg equilibrium using the XI test. Nonparametric tests including Kruskal-Wallis method and the Mann-Whitney U test were used to compare the DNA methylation levels between different genotypes. The allelic frequency distribution of the C1236T, C3435T and G2677T/A was found to be in good agreement with previous reports. Our study revealed significant correlation between different genotypes of C3435T and G2677TIA but there is no significant difference between the different genotypes of C1236T Conclusion: A correlation between MDR1 genetic polymorphisms C3435T and G2677T/A, as well as haplotypes derived from C1236T, G2677T/A and C3435T, with methylation status of MDR1 promoter region ...
- Central South University details research in DNA research.
- Newspaper article from: Proteomics Weekly May 11, 2009 700+ words
...Long and colleagues, Central South University. The researchers concluded...contact J.X. Wang, Central South University, College Chemical &...Analytical Chemistry, DNA, Central South University. This article was prepared...
- Central South University publishes research in pharmacokinetics.
- Newspaper article from: Biotech Week August 27, 2008 700+ words
...Xu and colleagues, Central South University (see also Pharmacokinetics...contact Y.G. Zhu, Central South University, Xiangya Hospital 2...Therapy, Treatment, Central South University. This article was prepared...
- Researchers from Central South University discuss findings in apoptosis.(Report)
- Newspaper article from: Biotech Week March 11, 2009 700+ words
...Zhang and colleagues, Central South University. The researchers concluded...contact Y.J. Li, Central South University, School Pharmaceutical...Therapy, Treatment, Central South University. This article was prepared...
- Research from Central South University has provided new data on bone research.
- Magazine article from: Women's Health Weekly March 5, 2009 700+ words
...Liu and colleagues, Central South University. The researchers concluded...contact R.C. Dai, Central South University, Xiang Ya Hospital 2...Therapy, Treatment, Central South University. This article was prepared...
- Research from Central South University has provided new information about...
- Newspaper article from: Cancer Gene Therapy Week June 1, 2009 700+ words
...Li and colleagues, Central South University. The researchers concluded...by contacting G. Li, Central South University, Cancer Research Institute...Pulmonology, Treatment, Central South University. This article was prepared...
- Research from Central South University provide new insights into stem cell...
- Newspaper article from: Angiogenesis Weekly April 24, 2009 700+ words
...Wu and colleagues, Central South University. The researchers concluded...contact G.X. Lu, Central South University, National Center Human...Tumor Vascularization, Central South University. This article was prepared...
- Scientists at Central South University describe research in hepatocellular...
- Newspaper article from: Angiogenesis Weekly March 20, 2009 700+ words
...Huang and colleagues, Central South University (see also Hepatocellular...contact G.W. Huang, Central South University, Xiangya Hospital, Dept...Endothelial Growth Factor, Central South University. This article was prepared...
- Studies from Central South University in the area of chromatography published.
- Newspaper article from: Science Letter August 5, 2008 700+ words
...Xu and colleagues, Central South University (see also Chromatography...contact B.K. Zhang, Central South University, Dept. of Clinic Pharmacy...Liquid Chromatography, Central South University. This article was prepared...
- Reports from Central South University advance knowledge in angiogenesis.
- Newspaper article from: Angiogenesis Weekly January 2, 2009 700+ words
...Wang and colleagues, Central South University. The researchers concluded...contact L.Y. Yang, Central South University, Liver Cancer Laboratory...Endothelial Growth Factor, Central South University. This article was prepared...
- Studies from Central South University in the area of vascular disease published.
- Newspaper article from: Blood Weekly January 1, 2009 700+ words
...Tang and colleagues, Central South University (see also Vascular Disease...contact F.Y. Tang, Central South University, Xiangya Hospital 2...Treatment, Vascular Disease, Central South University. This article was prepared...
Source: HighBeam Research, Research conducted at Central South University has provided new...