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Reports outline DNA research study findings from Duksung Women's University.
According to recent research published in the journal Chemical & Pharmaceutical Bulletin, "The multimerization of functional DNA alkylating agents has drawn significant, recent interest because these compounds are expected to generate enhanced levels of DNA cross-linked adducts, compared with their monomeric agents. Here we report the evaluation of 7-N,7'-N'-(1'',2'',9'',10''-tetrathia-cyclohexadecanyl-3'',8'',11'',16''-tetramethylenyl)tetrakismitomycin C (8), in which four mitomycin units are attached to the novel bis-disulfide linker, 3,8,11,16-tetrakis(aminomethyl)-1,2,9,10-tetrathia-cyclohexadecane."
"Compound 8 was designed to undergo preferential C(1) mitomycin activation under nucleophilic as well as under acidic and reductive conditions. We anticipated that treating 8 with nucleophiles would lead to bis-disulfide cleavage thus producing two mitomycin dimers (9) capable of generating
DNA interstrand cross-links (ISC). The mitomycin units in 9 are tethered by a stable carbon backbone linkage. According to the procedure reported by Lee and coworkers (Tetrahedron, 61, 1749-1754 (2005)), we synthesized 8 and the reference mitomycin dimer, 7-N,7'-N'-(2'',7''-dihydroxy-1'',8''-octanediyl)bismitomycin C (15). Compound 8 was activated under acidic conditions thereby generating mitosene product 16, in which all four mitomycin units ...
- Research from Duksung Women's University broadens understanding of life...
- Magazine article from: Women's Health Weekly March 26, 2009 700+ words
...wrote K.H. Lee and colleagues, Duksung Women's University. The researchers concluded...information, contact E.M. Choi, Duksung Women's University, Plant Resources Research...Pharmaceuticals, Drugs, Alternative Medicine, Duksung Women's University. This article was prepared...
- Researchers from Duksung Women's University provide details of new studies and...
- Newspaper article from: Health & Medicine Week June 22, 2009 700+ words
...wrote E.J. Choi and colleagues, Duksung Women's University. The researchers concluded...information, contact E.J. Choi, Duksung Women's University, Plant Resources Research...Apoptosis, Molecular Medicine, Duksung Women's University. This article was prepared...
- New science research from Duksung Women's University described.(Report)
- Newspaper article from: Food Weekly News August 20, 2009 700+ words
...wrote S. Kook and colleagues, Duksung Women's University. The researchers concluded...more information, contact K. Choi, Duksung Women's University, Dept. of Statistics...Database, Information Technology, Duksung Women's University. This article was prepared...
- Research on life sciences detailed by scientists at Duksung Women's University.
- Magazine article from: Women's Health Weekly January 29, 2009 700+ words
...wrote J.H. Lee and colleagues, Duksung Women's University (see also Life Sciences...information, contact C.S. Jeong, Duksung Women's University, College Pharmacy...Medicine, Analgesia, Inflammation, Duksung Women's University. This article was prepared...
- New findings reported from Duksung Women's University describe advances in life...
- Magazine article from: Women's Health Weekly October 9, 2008 700+ words
...effect on CYP1A1," wrote E.J. Choi and colleagues, Duksung Women's University. The researchers concluded: "The AhR...contact E.J. Choi, Plant Resources Research Institute, Duksung Women's University, Seoul, 132-714, Korea. Publisher contact...
- Data on pharmaceuticals described by researchers at Duksung Women's University,...
- Newspaper article from: Biotech Week May 6, 2009 700+ words
...working mechanisms," wrote S.H Lee and colleagues, Duksung Women's University, College of Pharmacy. The researchers concluded...information, contact S.H. Lee, College of Pharmacy, Duksung Women's University, Seoul, 132-714, Korea. The publisher...
- New DNA research research reported from H. Noguchi and co-authors.
- Newspaper article from: Biotech Week March 25, 2009 700+ words
...Noguchi and colleagues (see also DNA Research). The researchers concluded: "These...published the results of their research in DNA Research (MetaGeneAnnotator: Detecting Species...Anonymous Prokaryotic and Phage Genomes. DNA Research, 2008;15(6):387-396). For...
- New DNA research data have been reported by researchers at Suntory Ltd.
- Newspaper article from: Health & Medicine Week July 6, 2009 700+ words
...Osaka, Japan report (see also DNA Research). "Thirty-six different...colleagues published their study in DNA Research (Genome Sequence of the Lager...Yeast, an Interspecies Hybrid. DNA Research, 2009;16(2):115-129...