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Study results from Washington University, Medical Department broaden understanding of candidiasis.
According to a study from the United States, "A single large family, in which adolescent idiopathic scoliosis (AIS) and pectus excavatum (PE) segregate as an autosomal dominant condition, was evaluated. Genome-wide linkage analysis and candidate gene sequencing were performed."
"To map the disease-causing locus in a large white family in which AIS and PE cosegregate. AIS and PE are common musculoskeletal conditions known to have a genetic component, though few genes have been identified for either. Genetic studies have been confounded by a lack of large families in which the disorders segregate. Clinical examinations were performed on the proband, who underwent posterior spinal fusion, and 12 additional affected family members. To map a gene causing AIS and PE, a genome-wide linkage analysis was performed with the Affymetrix Mapping 10 K XbaI array on 13 affected and 10 unaffected family members. Candidate genes were sequenced. AIS was present in 13 female family members and PE was present in 3 males and 1 female. Genome-wide linkage analysis resulted in a linkage peak on chromosome 18 q with a maximum parametric multipoint logarithm of the odds score of 3.86. Recombinants delineated the critical genetic region to an interval of 6.4 cM between SNP_A-1519369 and SNP_A-1507702, corresponding to a 7.06-Mb region (hg18: chr18:26342508-34395660). The chromosome 18 q linkage region contains more than 30 genes. Resequencing of the coding regions of ...
- Washington University, Medical Department details research in bone marrow.
- Newspaper article from: Blood Weekly July 2, 2009 700+ words
...and colleagues, Washington University, Medical Department. The researchers...D.C. Link, Washington University, School Medical...Circulation, Washington University, Medical Department. This article...
- Washington University, Medical Department details research in stroke research.
- Newspaper article from: Blood Weekly May 21, 2009 700+ words
...and colleagues, Washington University, Medical Department (see also Stroke...M. Nassief, Washington University, School Medical...Urology, Stroke, Washington University, Medical Department. This article...
- Washington University, Medical Department details research in life sciences.
- Newspaper article from: Tuberculosis Week July 28, 2008 700+ words
...and colleagues, Washington University, Medical Department. The researchers...T. Chivers, Washington University, School Medical...Magnetic Resonance, Washington University, Medical Department. This article...
- Studies from Washington University, Medical Department describe new findings in...
- Newspaper article from: Biotech Week June 17, 2009 700+ words
...and colleagues, Washington University, Medical Department (see also Cerebral...R. Zazulia, Washington University, School Medical...Metabolism, Washington University, Medical Department. This article...
- Reports from Washington University, Medical Department advance knowledge in...
- Newspaper article from: Biotech Week June 17, 2009 700+ words
...and colleagues, Washington University, Medical Department. The researchers...J. Gardner, Washington University, School Medical...Orthopedics, Washington University, Medical Department. This article...
- Researchers at Washington University, Medical Department release new data on...
- Newspaper article from: Biotech Week June 17, 2009 700+ words
...and colleagues, Washington University, Medical Department. The researchers...R.A. Chole, Washington University, School Medical...Pseudomonas aeruginosa, Washington University, Medical Department. This article...
- Scientists at Washington University, Medical Department detail research in...
- Newspaper article from: Blood Weekly June 18, 2009 700+ words
...and colleagues, Washington University, Medical Department (see also Thrombosis...contact W.Z. Ray, Washington University, School Medical...Venous Thrombosis, Washington University, Medical Department. This article...
- Researchers at Washington University, Medical Department target diskectomy.
- Newspaper article from: Biotech Week June 24, 2009 700+ words
...and colleagues, Washington University, Medical Department. The researchers...D. Auerbach, Washington University, School Medical...Diskectomy, Surgery, Washington University, Medical Department. This article...
- Researchers from Washington University, Medical Department report recent...
- Newspaper article from: Clinical Trials Week June 22, 2009 700+ words
...and colleagues, Washington University, Medical Department (see also Breast...M.J. Ellis, Washington University, Siteman Cancer...Women's Health, Washington University, Medical Department. This article...
- Researchers from Washington University, Medical Department provide details of...
- Newspaper article from: Biotech Week June 3, 2009 700+ words
...and colleagues, Washington University, Medical Department. The researchers...contacting M. Tandon, Washington University, School Medical...Pharmacology, Washington University, Medical Department. This article...
Source: HighBeam Research, Study results from Washington University, Medical Department broaden...