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New research on arthritis from Catholic University summarized.

Women's Health Weekly

| April 02, 2009 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

In this recently published study, investigators in Rome, Italy conducted a study "To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis ( RA) and to define the possible association with autoantibody positivity and clinical outcome. Genomic DNA was obtained from two cohorts of patients with RA ( 100 with early RA ( ERA) and 114 with longstanding RA (LSRA)) and from 248 gender-matched controls from the same geographical area."

"Clinical and immunological characteristics were recorded for all the patients. The percentage of the 2/2 genotype was higher in patients with ERA (27.0%), and in patients with LSRA (34.2%), than in controls (14.9%) (ERA: OR = 2.11 (95% CI 1.20 to 3.70) vs controls; LSRA: OR = 2.96 ( 95% CI 1.76 to 5.00) vs controls). A lower representation of allele *3 was present in patients with ERA (2.0%) than in controls (6.0%; OR = 0.32 ( 95% CI 0.11 to 0.91)). No significant associations were found between polymorphisms and autoantibodies positivity," wrote B. Tolusso and colleagues, ...

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