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New enzyme research study findings have been reported from Tokyo Women's Medical University.
According to recent research from Tokyo, Japan, "The Eph-ephrin receptor-ligand system is implicated in cell behavior and morphology. EphA1 is the founding member of the Eph receptors, but little is known about its function."
"Here, we show that activation of EphA1 kinase inhibits cell spreading and migration in a RhoA-ROCK-dependent manner. We also describe a novel interaction between EphA1 and integrin-linked kinase ( ILK), a mediator of interactions between integrin and the actin cytoskeleton. The C-terminal sterile a motif (SAM) domain of EphA1 is required and the ankyrin region of ILK is sufficient for the interaction between EphA1 and ILK. The interaction is independent of EphA1 kinase activity but dependent on stimulation of the EphA1 ligand ephrin-A1. Activation of EphA1 kinase resulted in a decrease of ILK activity. Finally, we demonstrated that expression of a kinaseactive form of ILK (S343D) rescued the EphA1-mediated spreading defect, and attenuated RhoA activation," wrote T. Yamazaki and colleagues, Tokyo Women's Medical University (see also Enzyme Research).
The researchers concluded: ...
- Tokyo Women's Medical University details research in port-wine stain.(Report)
- Newspaper article from: Biotech Week July 22, 2009 700+ words
...wrote T. Kono and colleagues, Tokyo Women's Medical University. The researchers...additional information, contact T. Kono, Tokyo Women's Medical University, Dept. of Plast...Wine Stain, Therapy, Treatment, Tokyo Women's Medical University. This article...
- Tokyo Women's Medical University reports research in Graves disease.
- Newspaper article from: Heart Disease Weekly May 17, 2009 700+ words
...wrote K. Kato and colleagues, Tokyo Women's Medical University (see also Graves...additional information, contact K. Kato, Tokyo Women's Medical University, Dept. of Medical...Graves' Disease, Heart Attack, Tokyo Women's Medical University. This article...
- Tokyo Women's Medical University details research in monoclonal antibodies.
- Newspaper article from: Biotech Week October 7, 2009 700+ words
...wrote Y. Sawara and colleagues, Tokyo Women's Medical University (see also Monoclonal...additional information, contact T. Takei, Tokyo Women's Medical University, Dept. of Medical...Nephrotic Syndrome, Therapy, Treatment, Tokyo Women's Medical University. This article...
- Tokyo Women's Medical University reports research in phototherapy.
- Newspaper article from: Blood Weekly March 5, 2009 700+ words
...wrote M. Komori and colleagues, Tokyo Women's Medical University (see also Phototherapy...more information, contact M. Komori, Tokyo Women's Medical University, Medical Center...Photomedicine, Therapy, Treatment, Tokyo Women's Medical University. This article...
- Tokyo Women's Medical University publishes research in atopic...
- Magazine article from: Women's Health Weekly August 7, 2008 700+ words
...wrote S. Asano and colleagues, Tokyo Women's Medical University. The researchers...information, contact G. Imokawa, Tokyo Women's Medical University, Dept. of Dermatology...Atopic Dermatitis, Dermatology, Tokyo Women's Medical University. This article...
- Researchers from Tokyo Women's Medical University discuss findings in heart...
- Newspaper article from: Heart Disease Weekly October 11, 2009 700+ words
...wrote K. Matsuura and colleagues, Tokyo Women's Medical University (see also Heart...information, contact K. Matsuura, Tokyo Women's Medical University, Dept. of Cardiology...Research, Transplantation, Treatment, Tokyo Women's Medical University. This article...
- Scientists at Tokyo Women's Medical University describe research in Graves...
- Newspaper article from: Biotech Week November 4, 2009 700+ words
...wrote H. Kimura and colleagues, Tokyo Women's Medical University (see also Graves...additional information, contact K. Sato, Tokyo Women's Medical University, Institute Clinic...Pharmaceuticals, Therapy, Treatment, Tokyo Women's Medical University. This article...
- Studies from Tokyo Women's Medical University yield new data on lower back pain.
- Newspaper article from: Biotech Week October 21, 2009 700+ words
...wrote Y. Murata and colleagues, Tokyo Women's Medical University (see also Lower...additional information, contact Y. Murata, Tokyo Women's Medical University, Dept. of Orthopedic...Lower Back Pain, Therapy, Treatment, Tokyo Women's Medical University. This article...