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Study results from Catholic University provide new insights into diverticular disease.
According to a study from Rome, Italy, "The pathogenesis of symptoms of uncomplicated diverticular disease (UDD) is unclear, but changes in gut microflora and physiologic inflammation may be implicated. The objective of the study was to investigate the distribution of gut homing lymphocytes in peripheral blood and intestinal mucosa of UDD patients, and the effects of luminal antibiotic treatment."
"Ten UDD patients and 10 age- and gender-matched healthy subjects underwent peripheral blood sampling, and colonoscopy with biopsies taken from the transverse and sigmoid colon. Treatment consisted of a 2-month course of rifaximin 1.2 g/day for 15 days/month. Blood sample and mucosal biopsies were repeated in UDD patients at the end of treatment. Flow cytometry was performed using monoclonal antibodies (CD3, CD4, CD8, CD25, CD19, CD45, CD62L, CD103). In peripheral blood, both CD4+ and CD8+/CD103 + were significantly higher in patients at baseline than in controls (0.95% versus 0.36%, and 0.5% versus 0.09%, respectively). After treatment, peripheral CD4+/CD103+ decreased (0.27%), while CD8+/CD103+ did not change (0.35%); on the contrary, peripheral CD25+ increased, the CD4+ subpopulation showing significantly higher levels than those in controls. No difference was found between lymphocytes in the diverticular sigmoid mucosa of patients at baseline and those in controls, but there was a significant decrease in CD8+/CD62L+ after treatment. In the normal transverse colon, CD4+/CD62L+ of patient at baseline were significantly lower than in controls. After treatment, CD4+/CD103+ levels significantly increased, while ...
- New findings from A. Tursi and co-authors in the area of diverticular disease...
- Newspaper article from: Biotech Week September 9, 2009 700+ words
...current and evolving treatment of colonic diverticular disease' have been presented. "Formation of...development of diverticulosis and consequently diverticular disease. Diverticular disease can be associated with numerous debilitating...
- New diverticular disease therapy study findings recently were published by A....
- Newspaper article from: Biotech Week August 20, 2008 700+ words
...epithelial cell proliferation in colonic diverticular disease,' is now available. "Increased...proliferation may be detected in diverticular disease, but antibiotics have failed in...epithelial cell proliferation in diverticular disease," scientists in Andria, Italy...
- Reports on diverticular disease findings from Massachusetts General Hospital...
- Newspaper article from: Biotech Week December 10, 2008 700+ words
...and Painter who proposed that diverticular disease results from a deficiency of dietary fiber. Diverticular disease and diverticulitis are viewed...United States report (see also Diverticular Disease). "Our understanding of...
- Researchers from University of California report on findings in diverticular...
- Newspaper article from: Biotech Week June 24, 2009 700+ words
...WILLIAMS, P. T. Incident Diverticular Disease Is Inversely Related to Vigorous...published an isolated report of lower diverticular disease risk in physically active men...women reported clinically diagnosed diverticular disease since baseline. The risk for incident...
- New diverticular disease research from Frenchay Hospital outlined.(Report)
- Newspaper article from: Biotech Week May 20, 2009 700+ words
...laparoscopic surgery for complicated diverticular disease,' is the subject of a report...surgical management of complicated diverticular disease. A prospectively collected electronic...patients presenting with complicated diverticular disease," researchers in Bristol, the...
- Research on diverticular disease detailed by D.J. Humes and co-authors.
- Newspaper article from: Biotech Week May 20, 2009 700+ words
...United Kingdom, "Perforated diverticular disease represents the most serious complication of diverticular disease, but little is known regarding...using patients with perforated diverticular disease and population controls identified...
- Research reports from University of Toronto, University Health Network provide...
- Newspaper article from: Biotech Week September 24, 2008 700+ words
...Intramucosal ganglion cells are common in diverticular disease,' is the subject of a report...of intramucosal ganglion cells in diverticular disease, normal mucosa and in a spectrum...specimens from cases of symptomatic diverticular disease and biopsies and/or resection...
- Research from K. Piekarek and co-researchers in the area of diverticular...
- Newspaper article from: Biotech Week January 14, 2009 700+ words
"Perforated colonic diverticular disease is associated with a high...Sweden report (see also Diverticular Disease). "The use of substances...antimuscarinics on perforation in diverticular disease. A review of 54 patients...