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Research reports on autoimmune disease from University of Florida provide new insights.(Report)
"Previous studies have shown that treatment of ovariectomized females with 17-beta estradiol (E2) accelerates the development of autoimmunity in the (NZB x NZW)F-1 murine lupus model. Treatment with estrogenic organochlorine pesticides (OCPs) such as chlordecone produces a similar effect," scientists in the United States report (see also Autoimmune Disease).
"Although it is reasonable to postulate that the effects of chlordecone and related OCPs on autoimmunity are due to their estrogenic effects, this has not been clearly demonstrated. The objective of this study was to compare effects of chlordecone and E2 on splenic T lymphocyte parameters plausibly related to autoimmunity; specifically, on T-cell phenotype and functions. Ovariectomized (NZB x NZW)F-1 mice were treated for 6 weeks with implanted sustained-release pellets containing chlordecone or E2 at dosing rates shown previously to significantly shorten time to onset of disease. E2, but not chlordecone, increased the percentage of activated and memory CD4 T-cells, and reduced naive CD4 T-cells. E2 also elevated CD25 and glucocorticoid-induced TNF receptor (GITR) levels in CD4 T-cells, an effect not shared by chlordecone, On the other hand, both chlordecone and E2 increased Bcl-2 expression in CD4 T-cells and reduced CD4 T-cell apoptosis without affecting their proliferation. Although both treatments increased TNF-alpha and IL-2 secretion by CD4 T-cells, only chlordecone increased secretion of ...
- Researchers Identify Gene Involved in Autoimmune Disease.
- News wire article from: Ascribe Higher Education News Service July 25, 2002 700+ words
...to be a critical factor in autoimmune disease, according to a study to...molecular defects underlying autoimmune disease. Using molecular techniques...the genetic material from autoimmune disease-susceptible mice, scientists...
- LASIK may not be contraindicated in patients who have autoimmune disease.(laser...
- Magazine article from: Review of Optometry September 15, 2006 700+ words
The FDA listed autoimmune disease as a contraindication for LASIK...reasonable option in patients whose autoimmune disease is well controlled or inactive...Admittedly, the association between autoimmune disease, such as rheumatoid arthritis...
- Senators, Autoimmune Groups Host Briefing on Autoimmune Disease; Urge Funding...
- News wire article from: The America's Intelligence Wire March 25, 2004 700+ words
...Institutes of Health (NIH) Autoimmune Disease Research Plan. The group...their families who suffer from autoimmune disease. "Why is there such urgency to fund this research plan? Autoimmune disease strikes some 50 million Americans...
- INOVA Diagnostics, Inc. Lauded for its Leadership in the U.S. Autoimmune...
- Press release article from: PR Newswire August 1, 2007 700+ words
...Market Leadership in the U.S. autoimmune disease diagnostic markets. INOVA has been...that has excelled in every aspect of autoimmune disease testing and continues to outpace...Their exclusive dedication to autoimmune disease diagnostics has led to their undisputed...
- Examine Autoimmune Disease Therapeutics with this Essential Report.
- Press release article from: M2 Presswire October 16, 2008 700+ words
...Research and Markets: Examine Autoimmune Disease Therapeutics with this Essential...researchandmarkets.com/research/685be2/autoimmune_disease) has announced the addition of the "Autoimmune Disease Therapeutics" report to their...
- Researchers Discover Mechanism That May Trigger Autoimmune Disease.
- News wire article from: Ascribe Higher Education News Service April 30, 2003 700+ words
...discovered a mechanism that may trigger autoimmune disease in newborn babies. The research...inflammation in the study, an indication of autoimmune disease. Usually, T-cells help direct...the body's own cells and cause autoimmune disease. "The findings were unexpected...
- Limited Public Awareness Needs to Be Overcome to Realise Full Market Potential...
- Press release article from: M2 Presswire January 15, 2009 700+ words
...Potential with the European Autoimmune Disease Diagnostics(C)1994-2009...Sullivan's new report "European Autoimmune Disease Diagnostics Market" to their offering. The European autoimmune disease diagnostics market has demonstrated...
- National Institutes of Health to Present Landmark Autoimmune Disease Research...
- Press release article from: PR Newswire January 10, 2003 700+ words
...multi-agency research plan for autoimmune disease that the American Autoimmune Related...Children's Health Act, NIH's Autoimmune Disease Research Plan is the nation's first...incidence, diagnosis and treatment of autoimmune disease, as well as educate the medical...
- Echinacea and autoimmune disease.(Phytotherapy Review & Commentary)(Report)
- Magazine article from: Townsend Letter Bone, Kerry January 1, 2008 700+ words
...safety and value of Echinacea in autoimmune disease. Given the great variety of disorders...might not suit all patients with autoimmune disease. On this point, the few documented...cases and experimental models that autoimmune disease is often associated with a defective...
- Study Suggests Low-Dose Mercury Accelerates Autoimmune Disease.
- News wire article from: AScribe Health News Service September 2, 2003 700+ words
...association between mercury exposure and the autoimmune disease lupus. Their study, the first to connect...animals can exacerbate pre-existing autoimmune disease and even induce autoimmune disease in susceptible animals. "Our study...
Source: HighBeam Research, Research reports on autoimmune disease from University of Florida...