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Recent findings from Radboud University highlight research in antisense technology.
"Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to inactivating germline mutations in mismatch repair genes, including MSH2 (ref. 1). Here we describe patients from Dutch and Chinese families with MSH2-deficient tumors carrying heterozygous germline deletions of the last exons of TACSTD1, a gene directly upstream of MSH2 encoding Ep-CAM," scientists in Netherlands report (see also Antisense Technology).
"Due to these deletions, transcription of TACSTD1 extends into MSH2. The MSH2 promoter in cis with the deletion is methylated in Ep-CAM positive but not in Ep-CAM negative normal tissues, thus revealing a correlation between activity of the mutated TACSTD1 allele and epigenetic inactivation of the corresponding MSH2 allele. Gene silencing by transcriptional read-through of a neighboring gene in either sense, as demonstrated here, or antisense direction(2), could represent a general mutational mechanism," wrote M.J.L. Ligtenberg and colleagues, Radboud University.
The researchers concluded: "Depending on the expression pattern of the neighboring gene that lacks its normal ...
- Radboud University Nijmegen collaborates with Cordys Process Factory.
- Press release article from: M2 Presswire September 15, 2009 700+ words
...PRESSWIRE-15 September 2009-Cordys: Radboud University Nijmegen collaborates with Cordys...www.cs.ru.nl/) of the Radboud University Nijmegen has decided to collaborate...organised by the Science Faculty of the Radboud University Nijmegen, where students can compete...
- Radboud University Nijmegen and Cordys Link to Attract New Talent.
- Magazine article from: Health & Beauty Close-Up September 21, 2009 700+ words
...Computing and Information Science of the Radboud University Nijmegen has decided to collaborate...organized by the Science Faculty of the Radboud University Nijmegen, where students can compete...the audience will be expanded. Radboud University will invite 4,500 teachers and...
- Study results from Radboud University update understanding of...
- Newspaper article from: Biotech Week September 3, 2008 700+ words
...of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Center, The Netherlands...A.M. Renkema and colleagues, Radboud University (see also Orthodontics). The researchers...information, contact C. Katsaros, Radboud University, Medical Center, Dept. of Orthodontics...
- Radboud University publishes research in circumcision.
- Newspaper article from: Medical Devices & Surgical Technology Week August 9, 2009 700+ words
...wrote W. Dekkers and colleagues, Radboud University (see also Circumcision). The researchers...information, contact W. Dekkers, Radboud University, Institute Qual Healthcare, Medical...Nijmegen, Circumcision, Surgery, Radboud University. This article was prepared by Medical...
- Studies from Radboud University provide new data on cancer.
- Newspaper article from: Biotech Week July 29, 2009 700+ words
...wrote W. Kievit and colleagues, Radboud University (see also Cancer). The researchers...information, contact W. Kievit, Radboud University, Medical Center, Dept. of Rheumatol...Rheumatic Disease, Therapy, Treatment, Radboud University. This article was prepared by Biotech...
- Researchers from Radboud University detail findings in bladder cancer.
- Newspaper article from: Cancer Weekly July 28, 2009 700+ words
...wrote M. Ploeg and colleagues, Radboud University. The researchers concluded: "These...information, contact L.A. Kiemeney, Radboud University, Medical Center, Dept. of Urology...Carcinoma, Oncology, Urology, Radboud University. This article was prepared by Cancer...
- Scientists at Radboud University target vestibular schwannoma.(Report)
- Newspaper article from: Cancer Weekly July 28, 2009 700+ words
...C.A. Timmer and colleagues, Radboud University. The researchers concluded: "This...information, contact F.C.A. Timmer, Radboud University, Medical Center, Dept. of Otorhinolaryngology...Surgery, Vestibular Schwannoma, Radboud University. This article was prepared by Cancer...
- Researchers from Radboud University report on findings in business...
- Newspaper article from: Economics Week July 10, 2009 700+ words
...A.E. Geurts and colleagues, Radboud University. The researchers concluded: "Our...information, contact S.A.E. Geurts, Radboud University, Institute Behavioral Science...Life Sciences, Business Ethics, Radboud University. This article was prepared by Economics...
