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" Flatulence is a common symptom in patients with irritable bowel syndrome (IBS). This may be due to production of hydrogen by intestinal flora," scientists in Chandigarh, India report (see also Irritable Bowel Syndrome).
"With the presence of methanogenic flora, 4 mol of hydrogen (H-2) are used with 1 mol of carbon dioxide (CO2) to produce 1 mol of methane (CH4), a process greatly reducing the volume of gas in the colon. However, the prevalence of methanogenic flora has not yet been reported in healthy and IBS patients from North India. Therefore, this study was planned. This study was conducted prospectively and included 345 patients with irritable bowel syndrome (fulfilling Rome II criteria) and 254 age- and gender-matched apparently healthy controls. Each subject underwent a hydrogen breath test using 10 g lactulose after an overnight fast. An SC Microlyser from Quintron, USA, was used to measure methane and hydrogen at baseline and at every 30 min for 4 h. Subjects with fasting methane concentration 10 p.p.m. as predominant methane producers (PMPs). The IBS and control groups included 66.78% and 67.53% men, respectively. Mean age in the two groups was 48.52 +/- 30.54 years (range 15-68 years) and 45.67 +/- 30.54 years (range 15-78 years), respectively. Prevalence of predominant methanogenic flora in IBS and control groups was 14.5% (50/345) ...
Source: HighBeam Research, Research from S.V. Rana and co-researchers in the area of irritable...