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Researchers from University of Ulm report recent findings in hormones.(Report)
According to recent research from Ulm, Germany, "Adiponectin is an adipokine with profound antidiabetic and antiatherogenic effects. Circulating adiponectin concentrations are higher in women than in men."
"In order to study the molecular aspects of this sex-specific dimorphism, we examined the expression of adiponectin in human fat cells under the influence of sex hormones, using SGBS cells as an in vitro model. Androgen and estradiol receptor 1 and 2 (AR, ESR1, ESR2) mRNA expression increased dramatically during adipogenic differentiation. Stimulation with human male and female serum led to a downregulation of adiponectin expression, with male serum exerting significantly stronger inhibitory properties than female serum (p
The researchers concluded: "We hypothesize, therefore, the existence of a serum factor that is differently regulated by sex steroids and Subsequently causes the sex dimorphism in circulating adiponectin levels."
Horenburg and colleagues published their study in Hormone and Metabolic Research (Influence of Sex Hormones on Adiponectin Expression in Human Adipocytes. Hormone and Metabolic Research, 2008;40(11):779-786).
For additional information, contact M. Wabitsch, University of Ulm, Dept. of Pediatrics & Adolescent Medical, Division Pediatrics Endocrinol & Diabetes, Eythstr 24, D-89075 Ulm, Germany.
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