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Findings in Down syndrome reported from Copenhagen University.(Clinical report)
According to recent research from Copenhagen, Denmark, "Previous studies have found that 1 in 10 in vitro fertilization (IVF) singletons originates from a twin gestation. First trimester Down's syndrome screening markers are altered in assisted reproductive techniques (ART) pregnancies compared with spontaneously conceived pregnancies."
"The presence of a perished embryo may further complicate prenatal screening among women pregnant after ART. The aim of this study was to assess the impact of a 'vanishing twin' on first trimester combined biochemical and ultrasound screening in pregnancies conceived after IVF and intracytoplasmatic sperm injection. From a national prospective cohort study concerning first trimester combined screening among women pregnant after ART, 56 cases of pregnancies with a vanishing twin were identified. As control group 897 cases of ART singleton pregnancies were used. All women completed a first trimester combined ultrasound and biochemical screening programme comprising serum PAPP-A and free beta-hCG together with nuchal translucency (NT) measurement. There were no significant differences in geometric mean MoM free beta-hCG and PAPP-A between pregnancies with an early (gestational week
The researchers concluded: "No difference was seen for NT measurements."
Gjerris and colleagues published their study in Human Reproduction (The effect of a 'vanishing twin' on biochemical and ultrasound first trimester screening markers for Down's syndrome in pregnancies conceived by assisted reproductive technology. Human Reproduction, 2009;24(1):55-62).
For additional information, contact A.C. Gjerris, Copenhagen University Hospital, Dept. of Fetal Medical, Copenhagen, Denmark.
Publisher contact information for the journal Human Reproduction is: Oxford University Press, Great Clarendon ...
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Source: HighBeam Research, Findings in Down syndrome reported from Copenhagen...