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Researchers from University of Lethbridge detail new studies and findings in the area of DNA research.
"MicroRNAs as potent regulators of gene expression are involved in spermatogenesis, yet their role in response of germline to geno-toxic stress is obscure. We studied the microRNAome profile of X-ray irradiated mouse testes using the microarray technique," investigators in Lethbridge, Canada report (see also DNA Research).
"We found that radiation exposure significantly affected microRNA expression in testes. Mir-709 was the most abundant in both control and irradiated testes, and a big difference in miR-709 levels was observed between the control and exposed group. We found that miR-709 targets the Brother of the Regulator of Imprinted Sites (BORIS), an important regulator of DNA methylation and imprinting," wrote J. Tamminga and colleagues, University of Lethbridge.
The researchers concluded: "Here, we for the first time show that the DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation ...
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Source: HighBeam Research, Researchers from University of Lethbridge detail new studies and...