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Researchers from Ruhr University publish new studies and findings in the area of cytokines.
"Background., Major trauma induces a dysregulation of immune response supported in parts by lymphocyte dysfunction. Controversial data about a shift within the T-helper cell subsets Th1/Th2 are reported," scientists in Bochum, Germany report (see also Cytokines).
"To prove whether Th1/Th2-type cytokine plasma levels reflect the postulated Th2 shift after trauma, we investigated in a retrospective study 195 severely injured patients (47 women, 148 men; mean age 39.7 +/- 15.8 years; Injury Severity Score 32.0 +/- 11.3 points; overall 1,887 samples) during their ICU stay posttrauma. Mortality rate was 19%. Th1-type cytokines interleukin 2 (IL-2), interferon gamma, IL-12 (p70), and IL-18 and Th2-type cytokines IL-4, IL-10, and IL-11 were determined using the enzyme-linked immunosorbant assay technique in patients and in healthy controls. IL-2 and interferon gamma were seldom detectable. All other mediators were significantly increased matched to controls (p
The researchers concluded: "We conclude that in plasma no Th1/Th2 shift can be observed after major trauma."
Heizmann and colleagues published their study in the Journal of Trauma - Injury Infection and Critical Care (Th1-and Th2-Type Cytokines in Plasma After Major Trauma. Journal of Trauma - Injury Infection and Critical Care, 2008;65(6):1374-1378).
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