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According to recent research from Perth, Australia, "Measurement of BMD is a key factor in calculating the risk of osteoporotic fractures. In this Practice Point commentary, I discuss the clinical implications of a Swedish population-based longitudinal observation study that examined the association between BMD and levels of bone turnover markers (BTMs) measured at inclusion and at 1, 3 and 5 year follow-up in 573 women aged 75 years."
"Baseline BTM levels showed weak correlations with total body bone loss and femoral neck bone loss over 5 years. The correlations were strengthened when the mean of the four serial BTM measurements were used. Of the seven BTMs examined, serum C-terminal cross-linked telopeptide of type I collagen was the best predictor of bone loss," wrote S.D. Vasikaran and colleagues, Royal Perth Hospital, Medical Department (see also Bone Research).
The researchers concluded: "In addition to BMD and clinical risk factors, BTM measurement with standardized sample collection may be useful for management decisions, especially in patients with borderline ...