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New angiotensins data have been reported by J. Seidlerova and co-authors.
According to recent research published in the Journal of Human Hypertension, "Earlier studies have demonstrated the interaction between ADD1 and ACE in relation to arterial properties. We investigated whether arterial characteristics might also be related to interactions of ADD1 with other renin-angiotensin system genes."
"Using a family-based sampling frame, we randomly recruited 1064 Flemish subjects (mean age, 43.6 years; 50.4% women). By means of a wall-tracking ultrasound system, we measured the properties of the carotid, femoral and brachial arteries. In multivariate-adjusted analyses, we assessed the multiple gene effects of ADD1 (Gly460Trp), AGT (C-532T and G-6A) and AT1R (A1166C). In ADD1 Trp allele carriers, but not in ADD1 GlyGly homozygotes (P-value for interaction
The researchers concluded: "There is a single-gene effect of the AGT promoter haplotypes on brachial properties and PRA."
Seidlerova and colleagues published their study in the Journal of Human Hypertension (Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population. Journal of Human Hypertension, 2009;23(1):55-64).
For additional information, contact J.A. Staessen, Louvain University, Hypertension Unit, Studies Coordinating Center, Division Hypertension & Cardiovascular Rehabilitation, Dept. of Cardiovas, Campus Gasthuisberg, Herestr 49, Box 702, B-3000 ...
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