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Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers.(Report)

Phytomedicine: International Journal of Phytotherapy & Phytopharmacology

| December 01, 2008 | Modaghegh, Mohammad-Hadi; Shahabian, Masoud; Esmaeili, Habib-Allah; Rajbai, Omid; Hosseinzadeh, Hossein | COPYRIGHT 2008 Urban & Fischer Verlag. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Abstract

Saffron (Crocus sativus) stigma tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. The study was a double-blind, placebo-controlled design consisting of a 1 week treatment of saffron tablets. Volunteers were divided into 3 groups of 10 each (5 males and 5 females). Group I received placebo; groups 2 and 3 received 200 and 400 mg saffron tablets, respectively, for 7 days. General measures of health were recorded during the study such as hematological, biochemical and electrocardiographic parameters done in pre- and post-treatment periods. Clinical examination showed no gross changes in all volunteers after ...

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