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New hypothyroidism data have been reported by A. Kothari and co-authors.
"There is considerable uncertainty about the management of hypothyroidism in pregnancy. Our aim was to establish the pattern of thyroxine dose adjustment needed and to determine the clinical reasons for these changes and the contributory factors," researchers in Greenford, the United Kingdom report (see also Hypothyroidism).
"Of 89 pregnancies, thyroxine dose was unchanged in 50, increased (by a mean of 38 micrograms) in 34, and decreased in 5. Twenty-three percent of women who were tested in the first trimester needed an immediate increase in thyroxine. One-quarter (26%) of the women who needed a gestational increase in thyroxine dose had had a recent pre-pregnancy increase in thyroxine requirement (compared with 0% in women on static dose in pregnancy, P
The researchers concluded: "Inadequate pre-pregnancy control of thyroid function is associated with a need to increase thyroxine dosage during pregnancy."
Kothari and colleagues published their study in Bjog - an International Journal of Obstetrics and Gynaecology (Hypothyroidism in pregnancy: ...
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Source: HighBeam Research, New hypothyroidism data have been reported by A. Kothari and...