AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
New life sciences research from National University, Medical Department outlined.
"Proarrhythmic drugs induce long QT syndrome more frequently in women than men. The present study was designed to determine whether androgens regulate the function and expression of the human ether-a-go-go-related gene (HERG) encoded K+ channel, which is largely responsible for determining the QT interval," scientists writing in the journal Endocrinology report (see also Life Sciences).
"In a concentration-dependent manner (10(-9) to 10(-6) M for 24 h), 5 alpha-dihydrotestosterone (5 alpha-DHT) increased HERG protein abundance in HEK293 cells stably expressing HERG in the presence of coexpressed cardiac androgen receptor (AR) variant [N-terminal truncated isoform of AR (AR45)]. The elevation of HERG protein was seen in endoplasmic reticulum, Golgi, and plasma membrane without clear preferential colocalization. Coexpression of the more common form of the AR did not confer 5 alpha-DHT augmentation of HERG protein. Proteasome inhibitors, N-acetyl-L-leucyl-L-leucyl-L- norleucinal and MG132 prevented the 5 alpha-DHT dependent enhancement of HERG, as did the lysosome inhibitor, bafilomycin A1. Consistently, the cycloheximide-based protein chase study showed that 5 alpha-DHT prolonged HERG protein half-life. 5 alpha-DHT/AR45 signaling induced phosphorylation of ERK1/2. Blockade of ERK1/2 with PD98059 and U0126 prevented the effect of androgen on HERG protein abundance. Functional studies showed that 5 alpha-DHT treatment for 24 h increased HERG K+ current density in Chinese hamster ovary cells cotransfected with cDNAs of ...
- Research from Chonnam National University, Medical Department reveals new...
- Newspaper article from: Angiogenesis Weekly July 3, 2009 700+ words
...colleagues, Chonnam National University, Medical Department (see also Diabetic...K. Ahn, Chonnam National University, School Medical...Vitrectomy, Chonnam National University, Medical Department. This article was...
- Scientists at Seoul National University, Medical Department report research in...
- Newspaper article from: Diabetes Week April 13, 2009 700+ words
...colleagues, Seoul National University, Medical Department (see also Diabetes...M. Cho, Seoul National University, College Medical...Mellitus, Seoul National University, Medical Department. This article was...
- Research from Seoul National University, Medical Department broadens...
- Magazine article from: Women's Health Weekly July 2, 2009 700+ words
...colleagues, Seoul National University, Medical Department (see also Interstitial...of Urology, Seoul National University, 28 Yeon Geon Dong...Urology, Seoul National University, Medical Department. This article was...
- Scientists at Pusan National University, Medical Department target enzyme...
- Magazine article from: Women's Health Weekly March 19, 2009 700+ words
...colleagues, Pusan National University, Medical Department (see also Enzyme...H. Kang, Pusan National University, School Medical...s Health, Pusan National University, Medical Department. This article was...
- Researchers from Kyungpook National University, Medical Department report...
- Newspaper article from: Angiogenesis Weekly August 22, 2008 700+ words
...colleagues, Kyungpook National University, Medical Department (see also Colon...University, Kyungpook National University Hospital, School...Factor, Kyungpook National University, Medical Department. This article was...
- Investigators at National University, Medical Department have published new...
- Newspaper article from: Blood Weekly June 4, 2009 700+ words
...and colleagues, National University, Medical Department (see also Tissue...Shen, Singapore National University, Yong Loo Lin School...Tissue Engineering, National University, Medical Department. This article was...
- Scientists at National University, Medical Department discuss research in...
- Newspaper article from: Biotech Week May 20, 2009 700+ words
...and colleagues, National University, Medical Department (see also Chronic...Perng, Yang Ming National University, School Medical...Therapy, Treatment, National University, Medical Department. This article was...
- Researchers at National University, Medical Department target nasal polyps.
- Newspaper article from: Biotech Week May 20, 2009 700+ words
...and colleagues, National University, Medical Department (see also Nasal...Wang, Singapore National University, Yong Loo Lin School...Polyps, Surgery, National University, Medical Department. This article was...
- Reports from National University, Medical Department add new data to research...
- Newspaper article from: Blood Weekly March 19, 2009 700+ words
...and colleagues, National University, Medical Department (see also Proteinuria...Vathsala, Singapore National University, Yong Loo Lin School...Transplantation, Treatment, National University, Medical Department. This article was...
- Researchers from National University, Medical Department describe findings in...
- Newspaper article from: Virus Weekly March 17, 2009 700+ words
...and colleagues, National University, Medical Department (see also Dengue...Chu, Singapore National University, Yong Loo Lin School...Virology, Virus, National University, Medical Department. This article was...
Source: HighBeam Research, New life sciences research from National University, Medical...